In spite of the significant campaign for the equality and desirability of both sexes of children, empirical evidence and reality indicate that the practice of child-sex preference is still rampant in Nigeria. The study examined differentials in sex preference between rural and urban areas in Kaduna state. A total of 400 respondents, were sampled randomly for questionnaire administration with urban and rural areas having 200 respondents each. Focus Group Discussion (FGDs) and In Depth Interviews were employed to elicit information for the study. The collected data were analyzed respectively using frequencies in simple percentages and chi-square. Sex preference was found in both urban and rural areas of the state. However, majority of the rural respondents (57.5%) prefer more males and few female than those in the urban areas with (46.0%). Also, preference for more males and few females was higher among the men respondents (61.3%) when compared with the women respondents with (51.9%) in the rural areas. The chi- square result revealed a significant difference in sex preference in urban and rural areas (χ2= 13.616, df= 3, p-value = 0.003). Also, the study shows that perpetuation of family lineage accounted for the major reason for male child preference in both urban (52.5%) and rural (54.0%). It further revealed that support for old age and security as a reason for female preference was higher in the rural areas (57.0%) when compared with the urban areas (55.5%). In addition, the study showed that the absence of a preferred sex leads to continued child bearing in both urban and rural areas and this view was higher among the male respondents than the female respondents. The study further show that majority of the male respondents in both urban and rural areas agreed that the absence of a male child could result to marriage instability which was on the contrary in the absence of a female child, while the commonest type of instability experienced by couples in the absence of the preferred sex is sexual deprivation. The study therefore recommended that family education especially on sex equality and sensitivity should be carried out. Also, social insurance scheme by the government should be more effective especially in the rural areas to enable people move away from long time cultural belief that are gender bias.