CHAPTER ONE
INTRODUCTION
A wound refers to an injury to the skin or underlying tissues or organs (Agyare et al., 2013). Dermal wounds are often caused by surgery, trauma, and chemicals or as a result of diseases (Raina et al., 2008; Agyare et al., 2013). Intentionally created dermal wounds can be incisional, hereby the wound is brought about by surgically cutting into the skin with a scalpel or excision wound created when a part of the skin is cut off (Waldron and Trevor, 1993). The process of tissue repair after an insult to the tissue (wound) is called ‘wound healing’ (Nguyen et al., 2009). Wound
healing is an intricate process in which usually the skin repairs itself. The process involves four overlapping phases: haemostasis (ceasation of bleeding), inflammation, proliferation, and remodeling (Nguyen et al., 2009; Pandith et al., 2013). Inflammation is a pathophysiological response of living tissue to injuries that leads to the local accumulation of plasmic fluid and blood cells. The complex events and mediators involved in the inflammatory reaction can induce, maintain or aggravate many diseases (Shukla et al., 2010). However, studies have been continuing on inflammatory diseases and the side effects of currently available anti-inflammatory drugs pose a major problem during their clinical uses. Therefore development of newer and more substantial anti-inflammatory drugs with lesser side effects is necessary (Shukla et al., 2010).
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