INVITRO ANTI-OXIDANT CAPACITY OF YOYO BITTERS AND ITS NUTRITIONAL EFFECTS ON MALE ALBINO WISTAR RATS
ABSTRACT
In order to investigate invitro antioxidant capacity of yoyo bitters and its nutritional effect on the weight of male albino wistar rats. Sixteen(16) rats weighing (163±2.00g) were randomly picked into two equal group; (Group A and B). The rats were acclimatized for 7 days, after which 1ml 0f yoyo bitters were administered once daily to group A respectively for the period of 28 days while group B were received distilled water which serve as control. The feed was weighed throughout the period of the experiment. Each group were given 300g of mash grower feed daily and animals were also weighed weekly. At the end of 4 week, a significant increase was observed in the weight of the test rat (208.08±9.37g) compared to control (192.69±10.20g). The relative weight of the following organ: Liver, Kidney, Heart, Lungs, Spleen, Testes and Pancreas were observed and its was statistically significant (P<0.05). The total antioxidant capacity was compare using T test, the value of the test and control are statistically significant (P<0.05), Hydroxyl free radical n al activity (P<0.05) and DPPH scavenging activity (P<0.05).
CHAPTER ONE
1.0 INTRODUCTION
1.1 HERBAL BITTERS
Herbal medicine is “the knowledge, skills and practice based on the theories, beliefs and experiences indigenous to different cultures, used in maintenance of health and in the prevention, diagnosis, improvement or treatment of physical and mental illness” (W.H.O 2005). There are different systems of herbal medicine and the philosophy and practices of each are influenced by the prevailing conditions, environment, and geographic area within which it first evolved (W.H.O 2005), however, a common philosophy is a holistic approach to life, equilibrium of the mind, body and the environment and an emphasis on health rather than on diseases. Generally, the focus is on the overall condition of the individual rather than the particular ailment or disease from which the patient is suffering and the use of herbs is a core part of all system of traditional medicine. (Ergebreten 2002; Conboy et al., 2007; Rishon 2008, Schmidt et al., 2008).
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