The current status of methylenecyclopropane analogues of nucleosides has been reviewed including synthetic methodology for the first- and second-generation analogues, antiviral activity with emphasis on β– and γ-herpesviruses, structure-activity relationships and mechanism of action. Fluoromethylenecyclopropanes, nucleotide analogues and phenyl phosphoralaninate (PPA) pronucleotides are also discussed.
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